Mutaflor® capsules contain, as the active substance, the defined non-pathogenic strain Escherichia coli Nissle 1917 (EcN) and has been in clinical use for over 105 years.
The name Mutaflor, deduced from the Latin words mutare and flora, was meant to express the capability of the EcN strain to change the intestinal microflora by its antagonistic activity.
Mutaflor® is for the relief and management of chronic constipation. Your healthcare practitioner may also utilise this strain for its pharmacological, metabolic and immunomodulation properties.
The therapeutic effects of Mutaflor® are strain specific and have been demonstrated by in-vitro and in-vivo experiments and clinical studies, where the following properties and modes of action were detected.
Strain-Specific Characteristics of Escherichia coli strain Nissle 1917.
- The ability to colonize
- Antagonistic activity – Inhibition of growth and or killing of pathogens
- Anti-invasive – prevention of colonisation in the gut by pathogens
- Synthesis of endogenous antimicrobial peptides-defensins
- Mucosal integrity – contributing to luminal metabolism and stability of intestinal milieu-enhanced epithelial barrier function
- Anti-inflammatory and immunomodulatory effects
- Stimulation of colonic mucosa
Mutaflor® is a natural colonizer of the gut. E.coli strain Nissle 1917 is a normal, non-pathogenic and non-invasive inhabitant of the human gut. By means of special adhesive organelles (fimbriae) the strain is able to attach to the mucin layer of the gut wall. The strain is well mobile by possessing flagellae, an advantage when colonizing the colon.
Always read the label and use as directed. If symptoms persist talk to your healthcare professional.
Standard dose: 2 capsules daily
Constipation: Unless your Doctor or Healthcare Practitioner has suggested otherwise, the usual dose (standard dose) is:
Adults: For the first 2 days take 2 Mutaflor® capsules 3 times daily. From the third day onwards, take 4 Mutaflor® capsules daily. Repeat periodically or consult your healthcare professional.
Please read the Patient Information Leaflet for more information regarding Mutaflor®